Coconote
AI notes
AI voice & video notes
Export note
Try for free
Understanding Necrosis: Types and Morphology
Oct 19, 2024
Notes on Necrosis from Visual Pathology Lab Lecture
Introduction to Necrosis
Definition
: Necrosis is the result of proteolytic digestion of the cell and its contents.
Causes
:
Release of enzymes such as proteases and endonucleases due to cell injury.
Continuous cell injury leads to cell death.
Morphology of Necrosis
Different categories of necrosis exist based on the type of organ affected.
Visual aids, such as images, will be used to illustrate these types.
Types of Necrosis
1. Coagulative Necrosis
Characteristics
:
Occurs in solid organs that are not soft or rubbery.
Enzymatic leakage leads to cell injury and necrosis.
Mechanism
:
Leakage of proteolytic enzymes and rupture of cell membranes.
Architecture of the cell remains, but internal content is affected.
Examples
:
Spleen
: White areas represent coagulative necrosis.
Kidney
: Yellowish necrotic area shows infection.
Microscopic Features
:
Loss of cellular contact.
Eosinophilia (pinkish coloration of cytoplasm).
Nuclear changes: fading of nuclei, shrinkage (pyknosis), and dark color.
Comparison with normal tubules shows necrotic patches.
2. Ballooning Degeneration in the Liver
Characteristics
:
Cells become enlarged with eosinophilic cytoplasm and faded nuclei.
Comparison
:
Normal hepatocyte vs. ballooned hepatocyte, showing larger size and degeneration.
Accumulation of bile pigments.
3. Myocardial Necrosis
Characteristics
:
Typical example of coagulative necrosis.
Microscopic Features
:
Striated fibers in normal myocardium vs. necrotic myocardium.
Eosinophilic cytoplasm and fading nuclei.
In severe cases, the tissue may appear dirty due to cytoplasmic degradation.
Comparison
:
Tissue architecture becomes difficult to recognize; only tiny pyknotic nuclei may remain.
Conclusion
Coagulative necrosis is a significant pathological process in various organs.
Further types of necrosis will be discussed in subsequent videos.
📄
Full transcript