Overview
Dr. Mike from RP Strength discusses groundbreaking advances in muscle-building drugs, specifically combo therapies targeting muscle growth without traditional steroid side effects. He reviews recent primate study results, explores future human applications, and predicts major shifts in fitness, health, and drug use by 2027–2028.
Problems with Traditional Steroids
- Steroids increase muscle but cause significant androgenic side effects like hair loss, acne, aggression, poor lipid profiles, and hormonal disruption.
- Female users experience side effects such as voice deepening, facial hair growth, and menstrual irregularities.
- The need for muscle-building drugs without these side effects has long been recognized.
New Muscle-Building Drug Therapies
- Regeneron Pharmaceuticals has developed a combo of two drugs: Tvagramab (myostatin antagonist) and Gerrettmab (activin A antagonist).
- These drugs work by reducing myostatin and activin A, proteins that naturally limit muscle growth.
- The combination "uncaps" the body's natural muscle-building potential.
Primate Study Results
- Four groups: diet-only, semaglutide (weight loss drug), myostatin blocker, combo therapy.
- Diet-only monkeys lost moderate fat and minimal muscle.
- Semaglutide monkeys lost more fat but more muscle.
- Myostatin blocker group lost triple the fat of diet-only with no extra muscle loss.
- Combo group lost the most fat and, uniquely, gained muscle even on a caloric deficit.
- Results suggest combo therapy enables fat loss and muscle gain far beyond what is possible with existing drugs or diet alone.
Implications for Human Use
- Human trials are underway; similar results are expected due to biological similarity to primates.
- Drugs could allow for unprecedented muscle growth with minimal to no androgenic side effects.
- Potential release for public use projected around 2027–2028, pending FDA approval.
Projected Impact on Fitness and Health
- Steroids likely to become obsolete for muscle-building; TRT or drug-free approaches may become norm.
- Potential to radically reshape physique aesthetics, especially for those with poor genetics or older adults.
- Female users could see dramatic muscle gains without masculinizing side effects.
- Likely improvements in public health, reduced obesity, lower healthcare costs.
Predictions for Gym Culture and Society
- Gym attendance may remain steady or experience a renaissance among enthusiasts empowered by new drugs.
- Users can target specific muscle groups for enhanced aesthetics with greater effectiveness.
- Some may use drugs without exercising, still gaining health and appearance benefits.
Decisions
- Steroid use discouraged: Wait for new drug therapies rather than using traditional steroids.
- Combo therapy favored: Emerging drugs expected to supersede existing muscle-building pharmacology.
Action Items
- 2027–2028 – RP Strength/Community: Monitor FDA approval and prepare for integration of new therapies into training protocols.
- TBD – Interested Individuals: Review linked Regeneron research and stay informed on trial opportunities.