Muscle-Boosting Drugs and Future Trends

Folks who are older, folks who already really jacked, folks who aren't jacked at all or have just genetics, real talk, like it sucks to go to the gym and just claw for these minimal gains. This drug and drugs like it could end that forever. Now you get gains. Now you come to the gym and makes sense again. And every month your body looks better. Wow. You are going to be able to gain muscle at levels we barely see with the highest doses of steroids, which most people can't sustain for about a few weeks. with 10 times less side effects. If after a few generations, any side effects whatsoever. Modern pharma unleashed, you guys. Nobody playing. We look, nobody's playing anymore. Folks, the RP Strength summer sale is upon us. We've got tons of savings on all of our apps and a bunch of digital products. Click in the link down below in the description. Let's get started with today's video. Hey folks, Dr. Mike here for RP Strength and I have a very, very exciting chat to chat with you about. Scott, how come I suck at these intros? That was a good one. Yeah, killed it. Yeah, killed it. It's dead now. It's on the road. It's decomposing. In any case, folks, for a few years now, if you've been tuned in to this channel, if not, no big deal. Welcome. I've been yapping uncontrollably about the theoretical potential benefits of what are called non-androgenic anabolics. drugs that increase your skeletal muscle mass, which we all deeply desire, but at the same time have limited or no androgenic side effects. What are androgenic side effects? They include all the typical things that steroids give you because they do increase muscle mass, but they have all these androgenic side effects. hair loss, acne, increased body hair, which I know nothing about, worse lipid profile, not good, potential strain of the liver in some cases, definitely increases in aggression and anxiety, prostate enlargement, testicular atrophy, so you have to restart your testes after you come off. And for females, deepening of the voice, clitoral enlargement, which is soing hot, I will not make excuses about that, but most ladies find it confusing at best. Menstrual irregularities, and of course, facial hair growth, which females tend to find displeasing in most cases. So, the question is, why do steroids cause these? And the answer is steroids are not a muscle growth drug. They are a drug that is just designed to masculineize animals like all mammals and humans. And so when you increase the amount of androgens, the amount of androgenic anabolic steroids inside of a human, it does all the things that molecules do to make you more manlike, which means getting you more jacked for sure, but also means making you more aggressive, making you less verbally social, making you more anxious, making you have poor lipid profiles, and all the other stuff. of course, hair growth and all that stuff. These are side effects that are annoying. They're bad for your health and it makes it so that steroids are not like, "Hey, take this drug and it'll just get you jacked." There's a laundry list of problems with them. And I've done plenty of them and they suck. It's cool tool, but it's a really, really rough edge tool. If we could just have a drug that built a crapload of muscle but had no such androgenic side effects, it would be amazing. And in fact, this is now the reality because the brilliant minds at the Regeneron Pharmaceuticals Corporation have just such a drug and they have published research about it. And I want to tell you all about this drug until I'm just salivating about it. In fact, it's not just one drug. It's a combo drug therapy. It's true two drugs at the same time. Travagramab, good luck saying that one. And Gerrett Mab, good luck saying that one also. Who the makes these drug names up? I swear to God, Scott, there's a high probability in my mind that a gentleman named Trevor and a gentleman named Garrett co-discover these drugs and they just named it after themselves. Trevor and Garrett's drug. That's what I'm calling. So, Tvagramab is a myostatin antagonist. I'll get to what that is in just a little bit. And Gerrettmab is an act antagonist. Both drugs work by reducing the activity of myostatin and actin a myostatin and actin a predominant roles in skeletal muscle are to cap to hold down to reduce how much muscle you grow at any given time. And when these drugs unccort those caps, reduce the activity of myostatin and active and a you get this radical unleashing of completely natural in a sense muscle growth that your body wants to do all the time. But it has these two substances it makes itself these two proteins mastan and actin a capping this muscle growth all the time. What these drugs do is they go and unccort them you know in a dose dependent manner. The unccorking is partial and then complete if you take a crapload of these drugs. So, these new drugs uncap your body's natural potential for muscle growth. How well do they do it? Well, good news. We have an incredibly well-conducted research study by Regeneron Pharmaceuticals from their pre-stage one clinical trials. These are done on non-human primates, little teeny monkeys, you know, like the Outbreak SC. Remember Outbreak? That movie from the '90s? Dumbass monkeys bit everyone. Creepy. That's super creepy. Right. Monkeys are I don't monkeys at all. But if they're going to be given advanced anabolic drugs, I love monkeys. Monkeys, they're all family to me. Just I don't look them in the eye because they'll throw poop at you or whatever the hell. Nonhuman primates, which means there's very small monkeys. So, the amount of muscle gain and fat loss they're experiencing is measured in the grams and not in the kilograms. They're teeny teeny tiny. It's easier to do teeny teeny tiny because they experience rapid changes and it's easier to monitor them. And uh you know it's I guess they did they did put them to sleep and shove them in a DEXA which uh is quite impressive. So here's the deal. We have four groups of monkeys getting four different treatments. One group of monkeys had to diet. They restricted their calories a little bit and they dieted natty. These are natty monkeys, right? There are monkeys that go on forums and talk about everyone's a drug addict and they accuse everyone of taking drugs. Cope. Then there are monkeys that received simaglletide aka ompic which is a drug that is a modern weight loss drug mostly works by reducing your appetite. Another group of monkeys group three received only the myostatin blocker drug. Okay. And then group four received the myostatin blocker drug and the active a blocker drug. That real dual therapy. That tip of the spear. That's what we're testing there. So, four groups. Natty monkeys, simaglletide only monkeys, myostatin only monkeys, and then combo therapy monkeys. What occurred? We have a graph for you right here. Pause the video and look at the graph for a while. I'm going to explain it so you can pause and look after. This is wild, wild, wild, wild results. What are we looking at here? The monkeys that did the natty life and just dieted hardcore and probably bitched about it a lot. They lost about 400 grams. Remember, these are not small, these are not large animals, so 400 grams to them is actually a lot. They lost 400 gram of body fat with aboutish, these are very approximate numbers, 400ish grams of body fat and about 15ish grams of muscle loss. So something thereabouts, plus or minus 2x that number. So they lost a lot of fat and a very very small amount of muscle. I mean that's a really good ratio at 415. That's dope. That's almost no muscle loss. Monkeys taking simaglletide did what you would predict. They lost way way way more fat. Instead of 400 grams for the drug-free monkeys, the simaglatide monkeys lost about 700 gram of body fat thereabouts. Almost double, which is dope. The problem with simaglletide though is it's such a powerful reducer of how many calories you're taking in that the magnitude of your caloric deficit skyrockets. And we know in almost every case a very high caloric deficit leads to a higher proportion of muscle lost. That's just it's not a sagotype thing. It's not that the molecule is making you lose fat or sorry it's not like the molecule is making you lose muscle in some special way. It's just driving a crazy crazy deficit and then you lose more muscle. So those monkeys that were on some maglet they do they did lose 700 g versus 400 g of fat. Amazing. Almost 2x but they lost close to about 100 g of muscle with it. Still, hey, 7 to1 ratio is really good, but like, man, they lost maybe like five or six times more muscle than the monkeys that just did the natty. So, okay. All right, trade-offs. And it's like a known trade-off. No big deal. Here's the thing. The monkeys that were given some tvagramab, which is the myostatin blocker, lost about 1300 gram of body fat. Okay, real quick. Natty monkeys 400 gram loss of fat. Samaglletide monkeys 700 gram loss of fat. I can't I laugh when I say this. The triple the the the monkeys that got saglletide and the myostatin blocker tagramab lost, 1300 grams of fat. That is almost double the simaglletide group and more than three times the drug-free group. And those monkeys lost about 15 g of muscle. The we're talking about the same losses as the monkeys who lost 400 g of fat. Natty. Imagine a diet in which you lose the rough accum equivalent. I'll get to those numbers in a sec of 400 gram of fat. You lose a little teeny bit of muscle. Now I give you two things. I give you some magide and I give you trrammag. and you lose not 400 g of fat, but 1,300 g of fat and you lose no more muscle than you lost just on 400 g of fat. It's insane. It's insane. It's insane. This by itself will be a revolution. We now officially have a drug in Travagramab alone that nullifies the muscle loss effect seen from the massive deficits of simaglletide. So all those uh internet articles you've been reading and all those blog posts you've been reading about people who say oh saglletide loses muscle it's true because it lets you lose a lot of weight gone gone but it gets better monkeys that took the combo therapy they took some they took travagab and they took gretab and gretmab is the active a inhibitor so now we got mastadan inhibitor in the works and actin a those monkeys lost 1,400ish ish grams of fat. A little bit more, notably more than the monkeys that were just on the mouse inhibitor than group three, but not a ton more. But check this out. Those monkeys didn't lose 15 g of fat. Sorry, good god. Those monkeys didn't lose 15 g of muscle like the drug-free monkeys did or like the myostatin monkeys did. They didn't lose 100 grams of muscle like the simaglletide monkeys did. They gained on a deficit. By the way, monkeys don't resistance train. By the way, they gained 450 or so grams of muscle during the course of this diet, which was 20 weeks long, by the way. So, we're going from dieting drug-free. You lose a little bit of muscle, almost not at all, but you don't lose a whole lot of fat. To dieting with simaglletide, we use a lot more fat, but a substantial amount of muscle. Nothing crazy, but that's annoying. to adding in the myostatin inhibitor travagrammab and all of a sudden you are going to lose almost no muscle. Just a little bit of muscle loss, but you are losing almost double the amount of fat that you did with this simaglletide and close to just actually over three times the amount of fat that you did drug-free. And in the combo therapy the triple therapy simaglletide travagrammab and gretismab we got the GLP1 we've got the myostatin inhibitor and we have got the active and a inhibitor all combined into one into one vehicle into one drug. You're losing even more fat than you did with just myostatin by a little bit. You're now losing about double the fat that you did with simaglletide alone and close to four times the amount of fat you lost drug-free. What? But you are gaining the amount of muscle that is roughly equivalent to the amount of fat that you lost drug-free. This is insane. This is insane. Let's talk about some insights of this because this is totally wild stuff. This kind of drug, specifically this drug therapy is likely to transfer to humans because monkeys have a huge huge amount of commonalities with us, almost the same biology. And such studies are currently ongoing. They are in stage two clinical trials for this drug with humans now, which is like Scott, how do we get into this clinical trial, man? I'm sick. I'm dying out here, baby. Sign me up. Look at me in my no muscle mass. I need help. Please, Regeneron, please. Somebody email me from Regeneron, please. These trials are currently ongoing. There are multiple other pharmaceutical laboratories, mega corporations that are working around the clock on similar treatments because we now know for years that simaglletide and trespide and soon to be retatraide and all these weight loss drugs are phenomenal for helping people lose weight, but they don't really help you retain muscle. And now a lot of people losing weight and they're getting skinny and they have less muscle and they're getting all these health effects and all these cosmetic effects they don't like. This is a known problem to a pharmaceutical industry and now a ton of labs are rushing to get you the most advanced muscle growth drugs that they can make and already they are in research. The combo therapy that triple triple threat of simaglletide, travagrammab, and grretmab on fat loss and muscle gain are what we would expect with simaglletide plus a really solid dose of mega steroids for someone who's never taken steroids before except with zero androgenic side effects. No hair growth, no voice deepening, no aggression, no bad lipid profiles, none of that stuff. How big of a deal are these effects if we're going to extrapolate? Now, this is just pretend land for a second just to get our minds right. None nothing one to one here. So, just let's just just hypothesis stuff. Let's take the primate results and map them onto a human result. This is very likely what is going to happen or similar. Imagine you have an identical twin. Scott, what would you do if you had an identical twin other than masturbating in front of each other every day? I would do like twin shenanigans, you know, where we like dress up the same and get into high jinks. High jinks. you uh like date the same girl but you alternate alternatively date her. She's like remember we talked about like that one funny thing you said about chainsaws last time and your twin's like oh yeah of course yeah love chainsaws man. Yeah. He's texting you the table like what the did you talk to her about like that. However, you can do something even even cooler. You can both get on a diet. Isn't that nice? So imagine you have an identical twin and you're both a decent bit out of shape. Let's say you're about 200 lb both and you're both at about 20% body fat. Your twin is a natty four life. There's a number four in there somewhere. He's going to diet it for 5 months straight reasonably, drug-free. And extrapolating this primate data, he would lose as a group one monkey. He would You come up to your twin, you're like, "You're a group one monkey." He's like, "Shut up." Anyway, he would lose about 8 lbs of fat and lose less than a pound of muscle. He would at the end of this diet, at the end of five uh months, be about 192 lbs and around 16.5% body fat. Hey, you look better, Scott. That's better, right? That's cool. That's enough for people at work to be like, "Hey, what are you doing? Looking good, right?" However, you, the other identical twin, took all the baby. Triple threat. Simaglatide, Tvagramab, Geratus. You took it all. At the end of that fivemonth diet, extrapolating from this primate data, you would lose about 28 pounds of fat while gaining 9 lb of muscle. That means while your twin was about 192 lbs at the end of the diet, you would be about 181. and your twin is around 16.5% fat at the end of the diet. You would be around 6.5% body fat. Scott, make this make sense. It doesn't. Modern pharma unleashed, you guys. Nobody playing. We looked, nobody's playing anymore. The difference in visual appearance between you and your twin would be wild. I mean, we're in a completely different era of body composition enhancement. You want to burn fat. You want to build muscle? Regeneron Pharmaceuticals has the sword of Athena to the clouds. Holy Let's just talk about really quick some of the implications of when this tidal wave of modern drugs hits the market around 2027 2028 or so after they go through the just perilously and stupidly long FDA approval process. Such drugs are likely going to have very minimal side effects. Most likely the side effects are going to come from increasing muscle mass still radically which means they're probably going to make you hungrier and require you to eat more protein but you can just take a slightly higher dose of sagllet appetite or retraide to offset that. So no big deal. The effects will be a huge positive on strength gain. Of course adding n pounds of muscle is going to do something. It's going to be a way better look and a huge boost to overall health because more muscle means better controlled and lower blood sugar, lower blood fats and about 20 other major health benefits. I just don't have time to get into. Having more muscle is usually a really, really, really awesome thing. Here's the thing also we have to extrapolate. This won't be the only drug out within a few years after this drug releases or really within a few months of its release cuz other labs are working on their own competitors right now. There will be numerous other drugs out. And these drugs over years and years, maybe over months and months with advanced AI research at that point in in history, they're going to get better and better and better, increasing how much muscle that they help you gain, decreasing how much fat uh that you you hold on your body. They help you lose more fat. And they'll decrease side effects, too. If there really are any side effects to speak of, which I'm sure there will be, but over time, the drugs will be less and less and less side effects. More muscle gain and more fat loss. Crazy. Here's the thing, another implication. Folks who currently use steroids and suffer through all their side effects, which I've been through uh for a large fraction of my life, will really have to ask themselves a question of why the hell are we using steroids at all? I think almost everyone who's currently using steroids will just switch to TRT, testosterone replacement therapy, or just go drug-free and just to feel good and perform well. And then the muscle growth part is just going to be handled by these drugs which do it much more directly and way way better. In addition to this, it's not just for fat loss and some I say n pounds of muscle over 5 months is an insane amount of muscle to gain. But it's not just some muscle gain and a radical fat loss. If you take a low level of simaglatide, trapatide or retatrotide, these weight loss drugs, or none at all, and you take a decent amount of these muscle building drugs, and you eat in a slight surplus, Scott, are we even imag Like imagine eating a 500 calorie surplus when you're on the I can't imagine. Your delts are going to like pop off your head and you're going to die or some like that. you are going to be able to gain muscle at levels we barely see with the highest doses of steroids mo most people can't sustain for about a few weeks with 10 times less side effects if after a few generations any side effects whatsoever another thing is this okay not everyone wants to be like a gigantic Godzilla like you know what I'm saying busting up Tokyo if you train only or mostly muscles which you think improve your aesthetics for example your forearms your biceps triceps shoulders upper pecs upper back, a little bit of legs, and some some decent calf training, you can radically change your physique. Because generally when people train, and even if they take steroids, or even if they don't, they train whole body. If your whole body gets more muscular and like based on your genetics, like everything's bigger and you're leaner, which looks cooler, but you don't exactly have that aesthetic flow, like your arms are still a little bit small and shoulders small compared to your chest and back. Your quads and glutes are really big, but your calves aren't that big, so you kind of look like you have peg legs. These drugs are so powerful that they'll maintain or increase muscles you're not even training. And so if you take a moderate dose of this drug, even a low dose, and train the living crap out of muscles you want to increase that are really aesthetic, shoulders, upper back, upper chest, arms, forearms, and calves specifically, you're going to take your body and make it way more aesthetically appealing. Basically, you're going to turn into some version of me. Scott, can we get these pictures thrown up here? some version of me into some version that looks more like Jared Feather IFBB Pro because that's really what we all want to look like if we're being honest to ourselves in the middle of the night while touching ourselves. Of course, look at Jared's body. So, not only are people going to be able to get as jacked as they like, but they're going to be able to look more aesthetic, which is a huge, huge unlock. Here's another one. Females will stop taking steroids altogether. We'll see a renaissance of female physique sport the likes of which we've never seen. You'll see way more muscular females, but without any of the pimples or the hair loss or the hair growth on a whole range of women just don't want. Regular folks who aren't even in the gym because they have such crap genetics or just just have not been able to get just get their claws into the fitness industry. Um they'll be able to hit the gym and sculpt their bodies to their desire. Will some folks just take these drugs and not go to the gym? Absolutely. God bless them. Whatever. We don't need them in the gym crowding up this But at least now they're in way better health, way more muscle, way less fat. Our medical system saves billions of dollars and people are healthier and happier and look better. This is a big deal. And my prediction on gyms specifically is that we might see a decline in overall general gym attendance or maybe about the same, but we're going to see a second renaissance. The first one was in the in the 70s and 80s, really in the 80s if you think about it, of hardcore gym attendance because hardcore folks like most of you watching, many of you watching, if you're given a drug that radically increases muscle growth, that doesn't mean you stop going to the gym. That means you go to the gym more because you're more empowered to make a more perfect version of yourself. Scott, can you imagine when steroids really started becoming popular in the 80s that people just left the gym in droves? They're like, I'll just do steroids. I don't need the gym anymore. That's backwards, right? Yeah. Like Scott, if you're given this drug and you're able to train your body to make it even more aesthetic, are you leaving the gym or are you hitting the gym? We're hitting a baby. We're hitting it hard cuz now you guys, real talk, like human to human, folks who are older, folks already really jacked, folks who aren't jacked at all or have just genetics, real talk. Like it sucks to go to the gym and just claw for these minimal gains. Or just like work out for a year and see nothing happen or just slow the decline of muscularity in your 40s or 50s. That blows. It's good that you're doing it. Stay in the gym, but it blows. This drug and drugs like it could end that forever. Now you get gains. Now you come to the gym and makes sense again. And every month your body looks better. Wow. Okay, I could go on and on about the benefits, but for the purposes of time, I got to cut this video off in just a little bit. Suffice it to say that massive changes are inbound for the incredibly better for all of us. It's likely that these drugs pass FDA approval sometime 2027, 2028. So, it's just a few years away. Which means that if you are considering using steroids and you haven't used them yet, don't use them. Just don't use them. You won't need them soon. These drugs are a category above steroids entirely. They outclass them. Steroids are going to be dead in the water. Why take steroids if you have these drugs? Yeah, maybe for strength and asthma if you're a powerlifter or some like that. Cool. But for body composition, for getting jacked and lean, these drugs will end steroids. That is my sincere prediction. When these drugs come out, they're going to get us much closer to the purpose of what I call the aesthetic revolution. This is a big part of it. And the aesthetic revolution has one goal, getting everyone into the bodies they want to be in. That is our goal at RP. That is our express only reason the company exists. We have the RP hypertrophy app link in the description if you guys want to train and get your get your swoll on. Soon that app will have mega help and you can use the app plus these drugs to become the absolute most jacked lean and aesthetic version of yourself so you can impose properly. Are you excited? I sure am. We have a link to the entire Regeneron presentation in the description. Give that a click. Look through it and bask and marvel at advanced pharmaceuticals. You ready? I'm ready. I'll see you next time. [Music]

Folks who are older, folks who already really jacked, folks who aren't jacked at all or have just genetics, real talk, like it sucks to go to the gym and just claw for these minimal gains. This drug and drugs like it could end that forever. Now you get gains. Now you come to the gym and makes sense again. And every month your body looks better. Wow. You are going to be able to gain muscle at levels we barely see with the highest doses of steroids, which most people can't sustain for about a few weeks. with 10 times less side effects. If after a few generations, any side effects whatsoever. Modern pharma unleashed, you guys. Nobody playing. We look, nobody's playing anymore. Folks, the RP Strength summer sale is upon us. We've got tons of savings on all of our apps and a bunch of digital products. Click in the link down below in the description. Let's get started with today's video. Hey folks, Dr. Mike here for RP Strength and I have a very, very exciting chat to chat with you about. Scott, how come I suck at these intros? That was a good one. Yeah, killed it. Yeah, killed it. It's dead now. It's on the road. It's decomposing. In any case, folks, for a few years now, if you've been tuned in to this channel, if not, no big deal. Welcome. I've been yapping uncontrollably about the theoretical potential benefits of what are called non-androgenic anabolics. drugs that increase your skeletal muscle mass, which we all deeply desire, but at the same time have limited or no androgenic side effects. What are androgenic side effects? They include all the typical things that steroids give you because they do increase muscle mass, but they have all these androgenic side effects. hair loss, acne, increased body hair, which I know nothing about, worse lipid profile, not good, potential strain of the liver in some cases, definitely increases in aggression and anxiety, prostate enlargement, testicular atrophy, so you have to restart your testes after you come off. And for females, deepening of the voice, clitoral enlargement, which is soing hot, I will not make excuses about that, but most ladies find it confusing at best. Menstrual irregularities, and of course, facial hair growth, which females tend to find displeasing in most cases. So, the question is, why do steroids cause these? And the answer is steroids are not a muscle growth drug. They are a drug that is just designed to masculineize animals like all mammals and humans. And so when you increase the amount of androgens, the amount of androgenic anabolic steroids inside of a human, it does all the things that molecules do to make you more manlike, which means getting you more jacked for sure, but also means making you more aggressive, making you less verbally social, making you more anxious, making you have poor lipid profiles, and all the other stuff. of course, hair growth and all that stuff. These are side effects that are annoying. They're bad for your health and it makes it so that steroids are not like, "Hey, take this drug and it'll just get you jacked." There's a laundry list of problems with them. And I've done plenty of them and they suck. It's cool tool, but it's a really, really rough edge tool. If we could just have a drug that built a crapload of muscle but had no such androgenic side effects, it would be amazing. And in fact, this is now the reality because the brilliant minds at the Regeneron Pharmaceuticals Corporation have just such a drug and they have published research about it. And I want to tell you all about this drug until I'm just salivating about it. In fact, it's not just one drug. It's a combo drug therapy. It's true two drugs at the same time. Travagramab, good luck saying that one. And Gerrett Mab, good luck saying that one also. Who the makes these drug names up? I swear to God, Scott, there's a high probability in my mind that a gentleman named Trevor and a gentleman named Garrett co-discover these drugs and they just named it after themselves. Trevor and Garrett's drug. That's what I'm calling. So, Tvagramab is a myostatin antagonist. I'll get to what that is in just a little bit. And Gerrettmab is an act antagonist. Both drugs work by reducing the activity of myostatin and actin a myostatin and actin a predominant roles in skeletal muscle are to cap to hold down to reduce how much muscle you grow at any given time. And when these drugs unccort those caps, reduce the activity of myostatin and active and a you get this radical unleashing of completely natural in a sense muscle growth that your body wants to do all the time. But it has these two substances it makes itself these two proteins mastan and actin a capping this muscle growth all the time. What these drugs do is they go and unccort them you know in a dose dependent manner. The unccorking is partial and then complete if you take a crapload of these drugs. So, these new drugs uncap your body's natural potential for muscle growth. How well do they do it? Well, good news. We have an incredibly well-conducted research study by Regeneron Pharmaceuticals from their pre-stage one clinical trials. These are done on non-human primates, little teeny monkeys, you know, like the Outbreak SC. Remember Outbreak? That movie from the '90s? Dumbass monkeys bit everyone. Creepy. That's super creepy. Right. Monkeys are I don't monkeys at all. But if they're going to be given advanced anabolic drugs, I love monkeys. Monkeys, they're all family to me. Just I don't look them in the eye because they'll throw poop at you or whatever the hell. Nonhuman primates, which means there's very small monkeys. So, the amount of muscle gain and fat loss they're experiencing is measured in the grams and not in the kilograms. They're teeny teeny tiny. It's easier to do teeny teeny tiny because they experience rapid changes and it's easier to monitor them. And uh you know it's I guess they did they did put them to sleep and shove them in a DEXA which uh is quite impressive. So here's the deal. We have four groups of monkeys getting four different treatments. One group of monkeys had to diet. They restricted their calories a little bit and they dieted natty. These are natty monkeys, right? There are monkeys that go on forums and talk about everyone's a drug addict and they accuse everyone of taking drugs. Cope. Then there are monkeys that received simaglletide aka ompic which is a drug that is a modern weight loss drug mostly works by reducing your appetite. Another group of monkeys group three received only the myostatin blocker drug. Okay. And then group four received the myostatin blocker drug and the active a blocker drug. That real dual therapy. That tip of the spear. That's what we're testing there. So, four groups. Natty monkeys, simaglletide only monkeys, myostatin only monkeys, and then combo therapy monkeys. What occurred? We have a graph for you right here. Pause the video and look at the graph for a while. I'm going to explain it so you can pause and look after. This is wild, wild, wild, wild results. What are we looking at here? The monkeys that did the natty life and just dieted hardcore and probably bitched about it a lot. They lost about 400 grams. Remember, these are not small, these are not large animals, so 400 grams to them is actually a lot. They lost 400 gram of body fat with aboutish, these are very approximate numbers, 400ish grams of body fat and about 15ish grams of muscle loss. So something thereabouts, plus or minus 2x that number. So they lost a lot of fat and a very very small amount of muscle. I mean that's a really good ratio at 415. That's dope. That's almost no muscle loss. Monkeys taking simaglletide did what you would predict. They lost way way way more fat. Instead of 400 grams for the drug-free monkeys, the simaglatide monkeys lost about 700 gram of body fat thereabouts. Almost double, which is dope. The problem with simaglletide though is it's such a powerful reducer of how many calories you're taking in that the magnitude of your caloric deficit skyrockets. And we know in almost every case a very high caloric deficit leads to a higher proportion of muscle lost. That's just it's not a sagotype thing. It's not that the molecule is making you lose fat or sorry it's not like the molecule is making you lose muscle in some special way. It's just driving a crazy crazy deficit and then you lose more muscle. So those monkeys that were on some maglet they do they did lose 700 g versus 400 g of fat. Amazing. Almost 2x but they lost close to about 100 g of muscle with it. Still, hey, 7 to1 ratio is really good, but like, man, they lost maybe like five or six times more muscle than the monkeys that just did the natty. So, okay. All right, trade-offs. And it's like a known trade-off. No big deal. Here's the thing. The monkeys that were given some tvagramab, which is the myostatin blocker, lost about 1300 gram of body fat. Okay, real quick. Natty monkeys 400 gram loss of fat. Samaglletide monkeys 700 gram loss of fat. I can't I laugh when I say this. The triple the the the monkeys that got saglletide and the myostatin blocker tagramab lost, 1300 grams of fat. That is almost double the simaglletide group and more than three times the drug-free group. And those monkeys lost about 15 g of muscle. The we're talking about the same losses as the monkeys who lost 400 g of fat. Natty. Imagine a diet in which you lose the rough accum equivalent. I'll get to those numbers in a sec of 400 gram of fat. You lose a little teeny bit of muscle. Now I give you two things. I give you some magide and I give you trrammag. and you lose not 400 g of fat, but 1,300 g of fat and you lose no more muscle than you lost just on 400 g of fat. It's insane. It's insane. It's insane. This by itself will be a revolution. We now officially have a drug in Travagramab alone that nullifies the muscle loss effect seen from the massive deficits of simaglletide. So all those uh internet articles you've been reading and all those blog posts you've been reading about people who say oh saglletide loses muscle it's true because it lets you lose a lot of weight gone gone but it gets better monkeys that took the combo therapy they took some they took travagab and they took gretab and gretmab is the active a inhibitor so now we got mastadan inhibitor in the works and actin a those monkeys lost 1,400ish ish grams of fat. A little bit more, notably more than the monkeys that were just on the mouse inhibitor than group three, but not a ton more. But check this out. Those monkeys didn't lose 15 g of fat. Sorry, good god. Those monkeys didn't lose 15 g of muscle like the drug-free monkeys did or like the myostatin monkeys did. They didn't lose 100 grams of muscle like the simaglletide monkeys did. They gained on a deficit. By the way, monkeys don't resistance train. By the way, they gained 450 or so grams of muscle during the course of this diet, which was 20 weeks long, by the way. So, we're going from dieting drug-free. You lose a little bit of muscle, almost not at all, but you don't lose a whole lot of fat. To dieting with simaglletide, we use a lot more fat, but a substantial amount of muscle. Nothing crazy, but that's annoying. to adding in the myostatin inhibitor travagrammab and all of a sudden you are going to lose almost no muscle. Just a little bit of muscle loss, but you are losing almost double the amount of fat that you did with this simaglletide and close to just actually over three times the amount of fat that you did drug-free. And in the combo therapy the triple therapy simaglletide travagrammab and gretismab we got the GLP1 we've got the myostatin inhibitor and we have got the active and a inhibitor all combined into one into one vehicle into one drug. You're losing even more fat than you did with just myostatin by a little bit. You're now losing about double the fat that you did with simaglletide alone and close to four times the amount of fat you lost drug-free. What? But you are gaining the amount of muscle that is roughly equivalent to the amount of fat that you lost drug-free. This is insane. This is insane. Let's talk about some insights of this because this is totally wild stuff. This kind of drug, specifically this drug therapy is likely to transfer to humans because monkeys have a huge huge amount of commonalities with us, almost the same biology. And such studies are currently ongoing. They are in stage two clinical trials for this drug with humans now, which is like Scott, how do we get into this clinical trial, man? I'm sick. I'm dying out here, baby. Sign me up. Look at me in my no muscle mass. I need help. Please, Regeneron, please. Somebody email me from Regeneron, please. These trials are currently ongoing. There are multiple other pharmaceutical laboratories, mega corporations that are working around the clock on similar treatments because we now know for years that simaglletide and trespide and soon to be retatraide and all these weight loss drugs are phenomenal for helping people lose weight, but they don't really help you retain muscle. And now a lot of people losing weight and they're getting skinny and they have less muscle and they're getting all these health effects and all these cosmetic effects they don't like. This is a known problem to a pharmaceutical industry and now a ton of labs are rushing to get you the most advanced muscle growth drugs that they can make and already they are in research. The combo therapy that triple triple threat of simaglletide, travagrammab, and grretmab on fat loss and muscle gain are what we would expect with simaglletide plus a really solid dose of mega steroids for someone who's never taken steroids before except with zero androgenic side effects. No hair growth, no voice deepening, no aggression, no bad lipid profiles, none of that stuff. How big of a deal are these effects if we're going to extrapolate? Now, this is just pretend land for a second just to get our minds right. None nothing one to one here. So, just let's just just hypothesis stuff. Let's take the primate results and map them onto a human result. This is very likely what is going to happen or similar. Imagine you have an identical twin. Scott, what would you do if you had an identical twin other than masturbating in front of each other every day? I would do like twin shenanigans, you know, where we like dress up the same and get into high jinks. High jinks. you uh like date the same girl but you alternate alternatively date her. She's like remember we talked about like that one funny thing you said about chainsaws last time and your twin's like oh yeah of course yeah love chainsaws man. Yeah. He's texting you the table like what the did you talk to her about like that. However, you can do something even even cooler. You can both get on a diet. Isn't that nice? So imagine you have an identical twin and you're both a decent bit out of shape. Let's say you're about 200 lb both and you're both at about 20% body fat. Your twin is a natty four life. There's a number four in there somewhere. He's going to diet it for 5 months straight reasonably, drug-free. And extrapolating this primate data, he would lose as a group one monkey. He would You come up to your twin, you're like, "You're a group one monkey." He's like, "Shut up." Anyway, he would lose about 8 lbs of fat and lose less than a pound of muscle. He would at the end of this diet, at the end of five uh months, be about 192 lbs and around 16.5% body fat. Hey, you look better, Scott. That's better, right? That's cool. That's enough for people at work to be like, "Hey, what are you doing? Looking good, right?" However, you, the other identical twin, took all the baby. Triple threat. Simaglatide, Tvagramab, Geratus. You took it all. At the end of that fivemonth diet, extrapolating from this primate data, you would lose about 28 pounds of fat while gaining 9 lb of muscle. That means while your twin was about 192 lbs at the end of the diet, you would be about 181. and your twin is around 16.5% fat at the end of the diet. You would be around 6.5% body fat. Scott, make this make sense. It doesn't. Modern pharma unleashed, you guys. Nobody playing. We looked, nobody's playing anymore. The difference in visual appearance between you and your twin would be wild. I mean, we're in a completely different era of body composition enhancement. You want to burn fat. You want to build muscle? Regeneron Pharmaceuticals has the sword of Athena to the clouds. Holy Let's just talk about really quick some of the implications of when this tidal wave of modern drugs hits the market around 2027 2028 or so after they go through the just perilously and stupidly long FDA approval process. Such drugs are likely going to have very minimal side effects. Most likely the side effects are going to come from increasing muscle mass still radically which means they're probably going to make you hungrier and require you to eat more protein but you can just take a slightly higher dose of sagllet appetite or retraide to offset that. So no big deal. The effects will be a huge positive on strength gain. Of course adding n pounds of muscle is going to do something. It's going to be a way better look and a huge boost to overall health because more muscle means better controlled and lower blood sugar, lower blood fats and about 20 other major health benefits. I just don't have time to get into. Having more muscle is usually a really, really, really awesome thing. Here's the thing also we have to extrapolate. This won't be the only drug out within a few years after this drug releases or really within a few months of its release cuz other labs are working on their own competitors right now. There will be numerous other drugs out. And these drugs over years and years, maybe over months and months with advanced AI research at that point in in history, they're going to get better and better and better, increasing how much muscle that they help you gain, decreasing how much fat uh that you you hold on your body. They help you lose more fat. And they'll decrease side effects, too. If there really are any side effects to speak of, which I'm sure there will be, but over time, the drugs will be less and less and less side effects. More muscle gain and more fat loss. Crazy. Here's the thing, another implication. Folks who currently use steroids and suffer through all their side effects, which I've been through uh for a large fraction of my life, will really have to ask themselves a question of why the hell are we using steroids at all? I think almost everyone who's currently using steroids will just switch to TRT, testosterone replacement therapy, or just go drug-free and just to feel good and perform well. And then the muscle growth part is just going to be handled by these drugs which do it much more directly and way way better. In addition to this, it's not just for fat loss and some I say n pounds of muscle over 5 months is an insane amount of muscle to gain. But it's not just some muscle gain and a radical fat loss. If you take a low level of simaglatide, trapatide or retatrotide, these weight loss drugs, or none at all, and you take a decent amount of these muscle building drugs, and you eat in a slight surplus, Scott, are we even imag Like imagine eating a 500 calorie surplus when you're on the  I can't imagine. Your delts are going to like pop off your head and you're going to die or some like that. you are going to be able to gain muscle at levels we barely see with the highest doses of steroids mo most people can't sustain for about a few weeks with 10 times less side effects if after a few generations any side effects whatsoever another thing is this okay not everyone wants to be like a gigantic Godzilla like you know what I'm saying busting up Tokyo if you train only or mostly muscles which you think improve your aesthetics for example your forearms your biceps triceps shoulders upper pecs upper back, a little bit of legs, and some some decent calf training, you can radically change your physique. Because generally when people train, and even if they take steroids, or even if they don't, they train whole body. If your whole body gets more muscular and like based on your genetics, like everything's bigger and you're leaner, which looks cooler, but you don't exactly have that aesthetic flow, like your arms are still a little bit small and shoulders small compared to your chest and back. Your quads and glutes are really big, but your calves aren't that big, so you kind of look like you have peg legs. These drugs are so powerful that they'll maintain or increase muscles you're not even training. And so if you take a moderate dose of this drug, even a low dose, and train the living crap out of muscles you want to increase that are really aesthetic, shoulders, upper back, upper chest, arms, forearms, and calves specifically, you're going to take your body and make it way more aesthetically appealing. Basically, you're going to turn into some version of me. Scott, can we get these pictures thrown up here? some version of me into some version that looks more like Jared Feather IFBB Pro because that's really what we all want to look like if we're being honest to ourselves in the middle of the night while touching ourselves. Of course, look at Jared's body. So, not only are people going to be able to get as jacked as they like, but they're going to be able to look more aesthetic, which is a huge, huge unlock. Here's another one. Females will stop taking steroids altogether. We'll see a renaissance of female physique sport the likes of which we've never seen. You'll see way more muscular females, but without any of the pimples or the hair loss or the hair growth on a whole range of women just don't want. Regular folks who aren't even in the gym because they have such crap genetics or just just have not been able to get just get their claws into the fitness industry. Um they'll be able to hit the gym and sculpt their bodies to their desire. Will some folks just take these drugs and not go to the gym? Absolutely. God bless them. Whatever. We don't need them in the gym crowding up this But at least now they're in way better health, way more muscle, way less fat. Our medical system saves billions of dollars and people are healthier and happier and look better. This is a big deal. And my prediction on gyms specifically is that we might see a decline in overall general gym attendance or maybe about the same, but we're going to see a second renaissance. The first one was in the in the 70s and 80s, really in the 80s if you think about it, of hardcore gym attendance because hardcore folks like most of you watching, many of you watching, if you're given a drug that radically increases muscle growth, that doesn't mean you stop going to the gym. That means you go to the gym more because you're more empowered to make a more perfect version of yourself. Scott, can you imagine when steroids really started becoming popular in the 80s that people just left the gym in droves? They're like, I'll just do steroids. I don't need the gym anymore. That's backwards, right? Yeah. Like Scott, if you're given this drug and you're able to train your body to make it even more aesthetic, are you leaving the gym or are you hitting the gym? We're hitting a baby. We're hitting it hard cuz now you guys, real talk, like human to human, folks who are older, folks already really jacked, folks who aren't jacked at all or have just genetics, real talk. Like it sucks to go to the gym and just claw for these minimal gains. Or just like work out for a year and see nothing happen or just slow the decline of muscularity in your 40s or 50s. That blows. It's good that you're doing it. Stay in the gym, but it blows. This drug and drugs like it could end that forever. Now you get gains. Now you come to the gym and makes sense again. And every month your body looks better. Wow. Okay, I could go on and on about the benefits, but for the purposes of time, I got to cut this video off in just a little bit. Suffice it to say that massive changes are inbound for the incredibly better for all of us. It's likely that these drugs pass FDA approval sometime 2027, 2028. So, it's just a few years away. Which means that if you are considering using steroids and you haven't used them yet, don't use them. Just don't use them. You won't need them soon. These drugs are a category above steroids entirely. They outclass them. Steroids are going to be dead in the water. Why take steroids if you have these drugs? Yeah, maybe for strength and asthma if you're a powerlifter or some like that. Cool. But for body composition, for getting jacked and lean, these drugs will end steroids. That is my sincere prediction. When these drugs come out, they're going to get us much closer to the purpose of what I call the aesthetic revolution. This is a big part of it. And the aesthetic revolution has one goal, getting everyone into the bodies they want to be in. That is our goal at RP. That is our express only reason the company exists. We have the RP hypertrophy app link in the description if you guys want to train and get your get your swoll on. Soon that app will have mega help and you can use the app plus these drugs to become the absolute most jacked lean and aesthetic version of yourself so you can impose properly. Are you excited? I sure am. We have a link to the entire Regeneron presentation in the description. Give that a click. Look through it and bask and marvel at advanced pharmaceuticals. You ready? I'm ready. I'll see you next time. [Music]

Transcript for:Muscle-Boosting Drugs and Future Trends

Transcript for:
Muscle-Boosting Drugs and Future Trends