Side Effects of Anti-Tubercular Drugs

Overview

• Focus on the side effects of first-line anti-tuberculosis (TB) drugs.
• First-line drugs discussed:
  1. Rifampicin (Rifampin)
  2. Isoniazid
  3. Pyrazinamide
  4. Ethambutol

Specific Drugs and Their Side Effects

Rifampicin (Rifampin)

• Side Effect: Changes body fluids to an orange or red color.

Isoniazid

• Side Effect: Causes peripheral neuropathy.
  • Prevention: Administer Vitamin B6 (pyridoxine) as a preventive measure (rescue therapy).

Pyrazinamide

• Side Effect: Causes hyperuricemia.
  • Outcome: Increases uric acid levels in the blood, possibly leading to gout.

Ethambutol

• Side Effect: Causes red-green color blindness.
  • Comparison: Sildenafil (a phosphodiesterase 5 inhibitor) causes blue-green color blindness.

Common Side Effect

• Hepatotoxicity: Shared side effect of all four first-line anti-TB drugs.

Closing

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