Gastrointestinal Stimulants: Prokinetic Agents

Class: Prokinetic Agents (Dopamine Antagonists)

• Mechanism of Action: Stimulate peristalsis of the GI tract, promoting peristalsis.

Therapeutic Effects/Indications

• Nausea and Vomiting: Particularly those associated with chemotherapy or surgery.
• Delayed Gastric Emptying: Useful for patients with diabetic gastroparesis.

Precautions and Side Effects

• Renal Impairment: Monitor patients with a history of renal issues.
• Side Effects:
  • Sedation
  • Diarrhea
  • Extrapyramidal symptoms

Nursing Actions

• Assess renal function and neurofunction for patient safety.

Important Drug to Remember

• Prototype: Metoclopramide (Trade name: Reglan)
  • Function: Promotes peristalsis and increases gastric emptying.