Ondansetron (Zofran) Overview

Introduction

• Ondansetron, also known by the brand name Zofran, is a medication primarily used for treating nausea and vomiting.
• Important for NCLEX: Know the generic name, Ondansetron.

Memory Aid

• Mnemonic Device: Use the image of a dancer to remember Ondansetron ("dancer" sounds like "Ondansetron").
• Scenario: A daughter feeling stage fright, leading to nausea, being calmed by ginger ale, which helps in recalling that Ondansetron treats nausea.

Uses

• Primary Uses:
  • Treats nausea and vomiting.
  • Especially effective for post-operative or chemotherapy-induced nausea.

Mechanism of Action

• Belongs to the drug class of serotonin antagonists.
• Works by blocking serotonin signaling.

Side Effects

• Can cause serotonin syndrome, a rare but serious side effect:
  • Symptoms include:
    • Unstable vitals (tachycardia, hypertension)
    • Muscle rigidity
    • Agitation and restlessness
• Serotonin syndrome is a medical emergency and should be reported immediately.

Conclusion

• Remember: Ondansetron is important for treating nausea and vomiting.
• Be aware of serotonin syndrome as a potential rare side effect.

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