Understanding COMT Genetic Mutation

Introduction

• Podcast: Ultimate Human
• Hosts: Co-founders and co-hosts, including Sage Workinger (soon to be Sage Brea)
• Topics: Anti-aging, longevity, optimal health, biohacking

Genetic Methylation and COMT Mutation

• Genetic Methylation: Conversion of raw materials to usable forms in the body
• COMT Mutation: Catechol-O-methyltransferase mutation impacts mental and physical health

Key Points about COMT Mutation

• Neurotransmitter Regulation:
  • Downregulates catecholamines (fight or flight neurotransmitters)
  • High levels may cause anxiety, fright, or fight/flight response
• Estrogen Metabolism: Affects estrogen metabolism leading to possible estrogen dominance
• Characteristics of COMT Mutation:
  • Waking mind at night
  • Perfectionist and overthinking tendencies
  • OCD-like symptoms (not typical OCD)
  • Sensitivity to sounds, textures, and disorganization
  • Possible mild elevation in estrogen causing water retention around the belly button area

Sage's Experience with COMT Mutation

• Symptoms Before Diagnosis:
  • Difficulty falling asleep with racing thoughts (e.g., show tunes in mind)
  • Overthinking and worst-case scenario thoughts
  • Need for organization and cleanliness
• Behavioral Traits:
  • Problematic if not working for herself
  • Dependable, thorough, organized, hates being micromanaged

Practical Tips and Interventions

• Avoid Certain Foods and Supplements:
  • Green tea, quercetin, elderberry can aggravate symptoms
• Supplementation:
  • Essential Supplements: Methylfolate (5-MTHF), SAM-e, TMG (trimethylglycine), sleep formulas (melatonin, magnesium, theanine), 5-methyl-THF
  • B12 Forms: Methylcobalamin, Hydroxycobalamin (preferred for some with red COMT mutations)
• Lifestyle Adjustments:
  • Understanding individual genetic reports for better communication and personalized interventions
  • Regular supplementation to manage symptoms significantly improves life quality

Key Takeaways

• Individual Differences:
  • Not all genetic mutations manifest the same; personalization of treatment is key
  • Simple nutrient deficiencies can dramatically impact one's quality of life
• General Advice:
  • Getting tested for genetic mutations like COMT can guide effective dietary and supplement interventions
  • Emotional and physical well-being can be managed with proper supplementation and lifestyle adjustments

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Conclusion

• Emphasis on personalized health solutions based on genetic testing
• Encouragement to get tested and start supplementation for a better quality of life