wo ultimate human hey guys welcome back to the ultimate human podcast where we go down the road of everything anti-aging longevity Optimal Health biohacking and everything in between my guest today actually I don't think I should call her a guest should I call you the co-host yes co-founder okay all right my co-h habit you're the best thing that ever happened to you the best thing that ever happened to me my wife Sage workinger soon to be soon to be Sage Brea in any case today's podcast is about the genetic mutation CT we spent a lot of time talking about um genetic methylation you know this process of how the body takes raw materials that enter the human body and converts it to the UN usable form but we really actually take time to pull out one genetic mutation and explain it so that if you're listening and you have these types of characteristics and you've just accepted it as a consequence of Aging or a consequence of your lifestyle or your career or your diet or what have you it may not be a consequence of any of those things true it may s simply be a consequence of missing raw material in the human body the reason why we chose this Gene is because someone to my right has this gene mutation someone to my left does not which is why we are like the opposite when it comes to personality so let's talk about what CT which stands for cacal Oyl transferase that's not important um what this Gene really controls is it controls a few things number one it downregulates a category of neurotransmitters called catac colines now that might not sound like a big deal but catac colomines are fight ORF flight neurotransmitters and when they ride R in the brain they create a wakened state if they rise to a very high level they create a frightened State an anxious state or they could even create a fight ORF flight response and so if we have impaired ability to regulate these then there are certain consequences and some of the other things that it affects are estrogen metabolism we're going to talk about estrogen um so let's just talk about your journey with this gene mutation before we even knew that you had this this genetic mutation like what kind of things were going on oh so many fun things such as one weird topic that I don't think I ever I'm 45 years old I don't think I've ever shared this with anybody but before I started to supplement four my genetic breaks of which I have many um I would fall asleep well I would try to fall asleep and then as soon as my head hit the pillow even if I was exhausted from the day and thought I'd sleep so well my mind would turn on and I would have show Tunes songs that I don't really yeah I don't even go to Broadway plays but I'd have these show tunes just running through my head or a song I heard on the radio or and I and I would have that all throughout the day too and I just sort of thought that was normal so I till I started talking to people that don't have this Jean prak and they're like you don't have show tunes in your head at night that's weird um and then I I just I overthink everything no I know no I'm a worst kid scenario person which sucks when there's a knock on the door and you think it's a murderer every time yes every time um there was that Meme that was so funny where it was like a knock on the door and it's either a murderer or maybe the positive thinking book I ordered on Amazon yeah that's both you that was me to a te um but I over I'm a I'm a perfectionist I have I have OCD but you know the more I read about OCD it's not like the light switch flipping on and off kind of OCD but it's I like things in their place I like very organized I like my phone charger where my phone charger is supposed to be and I hate it when somebody to my left yes moves it out of place on a regular basis yeah and you know when we put some science behind what could be causing what is obsessive compulsive disorder like what is OCD or compulsive neatness I mean when we lack organization in the mind We crave organization in our outside environment because it's one less thing that we have to deal with one less disorganized thing we have to deal with so a lot of people listening this podcast will go wow I might have that gene mutation because when I go to study or work on a project not only does the desk I'm working on have to be clean but the room the desk is in has to be clean it's hard for me to work from home because if I see a pile of dishes in the sink or I know there's laundry to be done I feel like I have to get those things done even though that literally is not anything I need to deal with on that day um but once I take my vitamins then I recognized what needs to be put first need to get my emails done or phone calls made and not worry about the laundry I can do that later but it is hard for me I actually have to work on that every day whereas you don't ever do that at all no dises don't bother me ever worry neither does laundry in fact lot not a lot bothers me no yeah so I don't have that gene mutation but when you have this gene mutation the other one of the other consequences of these excess catacol means is that as your environment quiets your mind wakes up and it wakes up like all night long and so what does this mean it means that your body tired but your mind awake and I always talk about the kind of things that are going through your mind are the most innocuous little thoughts stupid stuff it could be really important things too like I stress a lot about the things that need to get done or things I didn't get done where nothing is particularly pressing like in your business or your career your relationship you might find yourself thinking about did I get everything on my grocery list today um did my outfit mesh my shoes you know I definitely don't care about that but yeah that it's never a worry but these are always innocuous little thoughts that that that could easily wait until the next day right um they don't need to be solved in that moment but they're keeping your mind awake and so once we start to put some um framework to understanding what how is it that I'm body tired and mind awake it's that these excess catacol beines this category of neurotransmitters flight neurotransmitters a fedrin a fedone um epinephrine or we also call Adrenaline um and dopamine and when we don't downregulate these the mind's in in a wakened state sometimes it's difficult to understand that we don't just create thought but we also dismantle thought we actually break thought down if not we would always be thinking the same things or we'd always be in the same mood yeah and so if we have a slow process of degrading thought transferring catacol amines I mean transferring methyl groups from the category of neurotransmitters called catacol amines if we're slow at this then the mind's in an awakened State and not only is the mind in awakened state but it's thinking and it's running through this Loop so like what are some of the things that you do to address that because if somebody's listening to this and they go okay great I really identify with her I've got the show tunes I've got the waking mind at night I'm a perfectionist have the perfectionism yeah it's I always say when when I do a lab review someone and I help them understand their comp te break I always try to show the good side of it because it really is a difficult Gene break to have uh mentally I always try to tell them that usually these are very successful entrepreneurs they can't work for anybody else they have a hard time you know taking Direction they hate we hate to be micromanaged if you try to micromanage me I'm out oh yeah I've tried yeah it doesn't work yeah um so that's why we have to work for ourselves and so that's a good sign because usually people become more successful that way they're also very dependable they're very reliable yes they're very thorough very thorough um you know they're the kind of people you want in your intuitive you want them in your group project when you're in school and you want them on your team when you own a business right if I look at somebody's Jean breaks when they start with uh 10x Health we after three months when somebody's with us 90 days we actually give them the gene test we provide that for them and I like to look at employees genetic reports because it helps me understand them it helps me understand what they're thinking what they're doing how they react to things and I can just communicate with them better knowing their personality you know the other thing that I wanted to mention um before we give some specific supplement recommendations is um you know early on when we were pulling your lab reports and looking at hormones nutrient deficiency es blood sugar control one of the things that always would pop up was this mild elevation in estrogen it always seemed to be slightly estrogen dominant and you're extraordinarily fit lean um you know um amazingly fit thank you and um I got abs for days actually she does have abs for days she has one of the greatest midsections any woman I've ever seen But when I was going through a period of time where I was taking the wrong vitamins you had this littleb yeah it was a bubble um which turns out is the estrogen band um right in my lower section rightow the belly button moving laterally around to the flanks and then back around towards like the kidneys and this particular area will drive women crazy we've had so many women come into the clinic and talk about gosh I just don't get it guys I'm not eating I have a cup of black coffee in the morning um I wake up fasted you know I go to Orange Theory for 55 minutes I've been doing that five days a week for three months I haven't lost a single pound like what is going on yeah and when you look at their hormones you realize that they're estrogen dominant meaning their estrogen is out of ratio so it's retaining water in what we call the interstitial space that space between cells and it has a tendency to gather right below the belly button laterally around the flanks but you also look at this comp T this CT gene mutation and you realize it plays a magnanimous role a very important role in estrogen metabolism it sends estrogen down what's called the E2 Pathway to help it get get rid of it and if we can't get rid of estrogen especially women it rises and it causes this water retention so these poor women that think they're fat are actually just retaining water yeah and so if you have some of these um personality characteristics um very organized um you know obsessively neat uh detail oriented maybe people tease you about having OCD you have this waking mind at night hey guys if you've been watching the ultimate human podcast for any length of time you know that one thing I do not do is push products I do not just let any Advertiser into the space because I believe that the products that appear on the ultimate human podcast should be things that I use every day in my life to 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with the loud loud sound the VII bed oh now the VII bed the majority of our clients love it it like even you would lay meditation bed Med vibro Acoustics red light therapy pmf but we had it out in kind of the living room den area of the house and if somebody got on it it it reverberated through the entire condo you hated it I remember I hated it so much but you thought I was being dramatic until Pete Vargas CH came over and he hated it too that's right remember and you had the same I was like see beat knows beat I'm not I'm not crazy and then you read about it remember when you're in La since I I read about the hyper Acuity and then that was when it like put it all together why does she get crazy you don't like a lot of Bright Lights loud music I don't like a lot of people either when it's like too overwhelming and there's too many people talking and right I just I have to back out I love that but she you don't no so knowing that you might have some of these characteristics right so somebody's listening and they go wow um I lay my head on the pillow my mind wakes up um I've got the show tunes and the active mind and I don't know what my hormones are but I do seem to have this estrogen band and because I have these other characteristics maybe I have this gene mutation if you get tested for this gene mutation and you are positive for it it's not the end of the Earth it's actually a very common gene mutation makes so many things make sense yes it's really helpful to know and so what have you done to mitigate it because now you're sleeping better your hormones are perfectly imbalanced you clearly don't have estrogen dominance anymore um I certainly don't notice the level of obsessiveness that you you know you had before so the big thing in my diet was that I had to get rid of green tea green tea everybody's like it's so healthy it is it's it's a wonderful tea if you don't have a comp tea Gene break it's the quatin in the green tea is so that's what it cuz I know then specifically you can't have quatin so a lot of quatin so during covid I recognized that a lot of doctors were prescribing quatin for their patients and recommending Elderberry as a supplement erable for comp boost your immune system and if I had Elderberry coratin and a green tea you can guarantee that I'd have a panic attack and lose my mind and definitely I would not sleep there was I remember looking back that I had a green tea because you were green tea obsessed for a while and we were at the Ritz Carlton one night with some patients yes and you were like oh it's good you drink it right before you order your food yes remember I drank it and I did not go to sleep until 8:00 in the morning I remember that I was like why in the I it's not something I regularly drink but and I definitely don't drink caffeine at night but it affected me way more than if I had had a coffee yeah and quatin which is commonly found in in almost all green tea and and elderberry quatin supplements if you have this genetic break you need to be very cautious about taking quatin because it will make your mind race it will um keep you up at night almost like a stimulatory effect because it creates this wake and mind State and it can significantly aggravate the estrogen metabolism um and further impair estrogen metabolism so that you become even more estrogen dominant and retain more fluid yeah um so if you think you might have this genetic mutation I noticed that Sage's routine is she takes methyl folate 5 mthf um for a while she used a supplement called Sam e which my that was a I always tell people when I started the protocol it took me about three tries to get it right right which because we are learning still I think we've figured it out for a lot of people but if anybody ever doesn't have the perfect reaction to the supplements I always encourage them to try to to mix it up and to try something new and the addition of Sam e Dr kept telling me I think you're going to really do well on it so I added it in and that first 3 days oh my gosh I remember you would like the happiest person you were like calling me going I'm the happiest I've ever met I feel great I literally felt like this huge weight was off my shoulders I was so happy I I remember this I called you I was on 41 in Naples and I called you you sound like my wife I don't even what's going on but I am so freaking happy right now and it was the addition of that Sam but it's not for everybody so it's very we don't ever put it on the first protocol for patients we always you know see how they do with the other vitamin supplements and then potentially we add it but um Sammy was great I take TMG triy gly trimethylglycine at night which helps me methylate better I take a sleep formula pill our capsule our formula is um melatonin magnesium and theanine which I love and then my trick is to take a five methyl F Aid at night as well because I have an MTHFR break so that helps me quiet my mind and get into bed she powered through the night last night I don't even I don't think you got up once last night it was glorious it was glorious um but you know having this sleep routine with methylfolate magnesium theine and melatonin um you know and the trimethylglycine during the day which you can take during the day or at night yeah you usually take it in the morning but the the the interesting thing is something as simple as regular supplementation to support a genetic deficiency a nutrient deficiency can make all the difference in the world in the entire trajectory of your life so many of you that are listening to this have these tiny little anchors off your Stern that you've accepted as a consequence of Aging it's either weight gain or water retention or brain fog or poor focus and concentration or lack of short-term recall or Waking mind at night or you get up at night to use the restroom and you can't go back s go back to sleep yeah miserable those things are not a consequence of Aging they are not something that you need to accept as a consequence of Aging these are generally a consequence of missing raw material deficiency in the human body and speaking of the raw materials so the the B12 specifically that I take uh now I have a yellow C tea which means I inherited it from one parent so I can get away with taking either methyl folate I'm sorry um methyl cobalamin methyl cobalamin or I could take yeah which is a really good B12 or you can take two better forms which is um hydroxy cobalamin or Adil cobalamin but if you have a red comp tea which means both parents passed on that genetic mutation or that genetic break to you then you have to take hydroxycobalamin or ad denil cobalamin because those are the top two forms you don't really do as well on methyl cobalamin right so you could put it to make it even more simple if you have the choice over B vitamins you could take a hydroxycobalamin or a cobalamin form and not have to worry about it yeah because everybody can process because everybody can process that and it's it's odd sometimes when we think well there's four forms of B12 um three of them occur naturally in nature one of them is actually synthetic we can't stand it it's called cyano Cal that'll turn me into a crazy person yeah you need to get that out of your life if it's in any of your supplements but your sanity your sleep your lack of brain fog your focus and attention your deep sleep your um non-racing thoughts your organization could be as simple and as far away as some very very simple nutrient deficiencies so I really encourage you you know to get that test done for the compy gene mutation if you have any of those symptoms and begin to supplement for those and possibly change the entire trajectory of your life it will be a total game Cher it's it's changed my life significantly it's changed both of our lives and and and the lives of thousands of our patients and I don't drive them as crazy as I used to this is this is true it actually has made our relationship a lot more common I'm sure I have Jean breakes that used to drive her crazy that are not anymore um so if you've enjoyed this podcast please don't forget to like And subscribe below this is the ultimate human podcast and as always that's just science if you haven't had a chance to connect with me on the ultimate human.com head over there now and sign up for my free newsletter and all of the exclusive content